The phrase osimertinib re-exposure, which has gained major interest in the healthcare sphere, refers to the process of reintroducing the same focused therapy, osimertinib, to patients who had initially responded to it but subsequently developed developed resistance.This idea yields several important deliberations, such as potential benefits, risks, and challenges related to rechallenge.This the article will examine the causes of osimertinib re-exposure, examine its repercussions for patients and medical practitioners, and discuss the necessary associated requirements.grasping the fundamental processes of developed resistance is crucial for effectively re-challenging patients with osimertinib.This section…