For patients with NSCLC (NSCLC), osimertinib, a specific treatment, has emerged as a revolutionary therapeutic method.This article provides a complete survey of osimertinib, including its way in which it works, clinical effectiveness, and its evolving role in the management of NSCLC.Osimertinib, a generation three EGFR (EGFR) TKI (TKI), selectively inhibits the EGFR tyrosine domain.Primarily used in the treatment of NSCLC patients with EGFR mutations, particularly those with T790M alterations, osimertinib is effective against tolerance to first stage and second phase EGFR TKIs.Clinical trials have shown osimertinib to be effective in…