The management of NSCLC (NSCLC) presents a major difficulty due to developed resistance to Tagrisso, a third-line EGFR TKI.The L861G mutation is one of the critical mutations that are responsible for this resistance.Resistance to Tagrisso arises due to this mutation, which is characterized by a leucine-to-glycine substitution at amino acid position 861.This review aims to provide a comprehensive review of the current understanding of developed resistance to the Tagrisso L861G mutation, exploring its mechanisms, possible treatment approaches, and future prospects.developed resistance arises in Tagrisso-resistant NSCLC cells due to the L861G…
